› 3eh2

X-ray diffraction
2.35Å resolution

Crystal structure of the human COPII-coat protein Sec24c

Released:
DOI: 10.2210/pdb3eh2/pdb
PDB entry 3eh2 coloured by chain, front view.
PDB entry 3eh2 coloured by chain, side view.
PDB entry 3eh2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.
Mancias JD, Goldberg J
EMBO J 27 2918-28 (2008)
PMID: 18843296

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156925 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein transport protein Sec24C Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 766 amino acids
Theoretical weight: 85.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53992 (Residues: 329-1094; Coverage: 70%)
Gene names: KIAA0079, SEC24C
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 69.69Å b: 182.98Å c: 201.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.241 0.284
Expression system: Spodoptera frugiperda

Quick links

Citations

44 review citations

COPII and the regulation of protein sorting in mammals.
Zanetti et al. (2012)
43 more

4 mentions without citation

Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway.
Cox et al. (2018)
3 more