› 3ehq

X-ray diffraction
2.57Å resolution

Crystal Structure of Human Osteoclast Stimulating Factor

Released:
DOI: 10.2210/pdb3ehq/pdb
PDB entry 3ehq coloured by chain, front view.
PDB entry 3ehq coloured by chain, side view.
PDB entry 3ehq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human osteoclast stimulating factor.
Tong S, Zhou H, Gao Y, Zhu Z, Zhang X, Teng M, Niu L
Proteins 75 245-51 (2009)
PMID: 19137598

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187798 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Osteoclast-stimulating factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 222 amino acids
Theoretical weight: 24.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92882 (Residues: 1-214; Coverage: 100%)
Gene name: OSTF1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P212121
Unit cell:
a: 48.057Å b: 56.86Å c: 170.125Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.21 0.284
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

Osteoclast stimulation factor 1 (Ostf1) KNOCKOUT increases trabecular bone mass in mice.
Vermeren et al. (2017)
3 more

2 mentions without citation

Structural and Energetic Characterization of the Ankyrin Repeat Protein Family.
Parra et al. (2015)
1 more