› 3eml

X-ray diffraction
2.6Å resolution

The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.

Released:
DOI: 10.2210/pdb3eml/pdb
PDB entry 3eml coloured by chain, front view.
PDB entry 3eml coloured by chain, side view.
PDB entry 3eml coloured by chain, top view.
Source organisms:
Primary publication:
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.
Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC
Science 322 1211-7 (2008)
PMID: 18832607

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132973 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 488 amino acids
Theoretical weight: 54.74 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29274 (Residues: 2-208, 222-316; Coverage: 73%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
Gene names: ADORA2, ADORA2A, E
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ZMA 1 x ZMA
Ligand STE 5 x STE
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 47.736Å b: 76.932Å c: 86.553Å
α: 90° β: 101.32° γ: 90°
R-values:
R R work R free
0.198 0.196 0.231
Expression system: Spodoptera frugiperda

Quick links

Citations

205 review citations

The structure and function of G-protein-coupled receptors.
Rosenbaum et al. (2009)
204 more

310 mentions without citation

Structure-function of the G protein-coupled receptor superfamily.
Katritch et al. (2013)
309 more