› 3eox

X-ray diffraction
2.61Å resolution

High quality structure of cleaved PAI-1-stab

Released:
DOI: 10.2210/pdb3eox/pdb
PDB entry 3eox coloured by chain, front view.
PDB entry 3eox coloured by chain, side view.
PDB entry 3eox coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High quality structure of cleaved PAI-1-stab.
Dewilde M, Strelkov SV, Rabijns A, Declerck PJ
J Struct Biol 165 126-32 (2009)
PMID: 19059484

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 42.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P3112
Unit cell:
a: 71.174Å b: 71.174Å c: 141.664Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.201 0.256
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Functional stability of plasminogen activator inhibitor-1.
Yasar Yildiz et al. (2014)
1 more

3 mentions without citation

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition.
Sillen et al. (2020)
2 more