› 3f3y

X-ray diffraction
2.2Å resolution

Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid

Released:
DOI: 10.2210/pdb3f3y/pdb
PDB entry 3f3y coloured by chain, front view.
PDB entry 3f3y coloured by chain, side view.
PDB entry 3f3y coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pan PW, Dong A, Amaya M, Edwards AM

Function and Biology Details

Reactions catalysed: 
3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfotransferase 2A1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 33.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06520 (Residues: 1-285; Coverage: 100%)
Gene names: HST, STD, SULT2A1
Sequence domains: Sulfotransferase domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand 4OA 4 x 4OA
Ligand A3P 4 x A3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 79.393Å b: 96.179Å c: 159.298Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.299
Expression system: Escherichia coli

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