› 3f4m

X-ray diffraction
1.7Å resolution

Crystal structure of TIPE2

Released:
DOI: 10.2210/pdb3f4m/pdb
PDB entry 3f4m coloured by chain, front view.
PDB entry 3f4m coloured by chain, side view.
PDB entry 3f4m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of TIPE2 provides insights into immune homeostasis.
Zhang X, Wang J, Fan C, Li H, Sun H, Gong S, Chen YH, Shi Y
Nat Struct Mol Biol 16 89-90 (2009)
PMID: 19079267

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor alpha-induced protein 8-like protein 2 Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P589 (Residues: 24-184; Coverage: 88%)
Gene name: TNFAIP8L2
Sequence domains: Domain of unknown function (DUF758)
Structure domains: Tumor necrosis factor alpha-induced protein 8-like

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU, BRUKER AXS MICROSTAR-H
Spacegroup: P6222
Unit cell:
a: 91.815Å b: 91.815Å c: 67.952Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.187 0.243
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Role of inflammation and its mediators in acute ischemic stroke.
Jin et al. (2013)
9 more

7 mentions without citation

Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease.
Lete et al. (2020)
6 more