› 3f59

X-ray diffraction
2Å resolution

Crystal structure of ZU5-ANK, the spectrin binding region of human erythroid ankyrin

Released:
DOI: 10.2210/pdb3f59/pdb
PDB entry 3f59 coloured by chain, front view.
PDB entry 3f59 coloured by chain, side view.
PDB entry 3f59 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the spectrin-ankyrin interaction binding domains.
Ipsaro JJ, Huang L, Mondragón A
Blood 113 5385-93 (2009)
PMID: 19141864

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147654 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ankyrin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 161 amino acids
Theoretical weight: 17.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16157 (Residues: 911-1068; Coverage: 8%)
Gene names: ANK, ANK1
Sequence domains: ZU5 domain
Structure domains: Chondroitinase Ac; Chain A, domain 3

Ligands and Environments

1 bound ligand:
Ligand BR 18 x BR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21
Unit cell:
a: 38.04Å b: 204.11Å c: 43.07Å
α: 90° β: 113.14° γ: 90°
R-values:
R R work R free
0.218 0.216 0.264
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Membrane domains based on ankyrin and spectrin associated with cell-cell interactions.
Bennett et al. (2009)
11 more

6 mentions without citation

Structures of the spectrin-ankyrin interaction binding domains.
Ipsaro et al. (2009)
5 more