› 3f5p

X-ray diffraction
2.9Å resolution

Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor

Released:
DOI: 10.2210/pdb3f5p/pdb
PDB entry 3f5p coloured by chain, front view.
PDB entry 3f5p coloured by chain, side view.
PDB entry 3f5p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Miller LM, Mayer SC, Berger DM, Boschelli DH, Boschelli F, Di L, Du X, Dutia M, Floyd MB, Johnson M, Kenny CH, Krishnamurthy G, Moy F, Petusky S, Tkach D, Torres N, Wu B, Xu W
Bioorg Med Chem Lett 19 62-6 (2009)
PMID: 19041240

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, R, S, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, R, S, T
Length: 308 amino acids
Theoretical weight: 35.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08069 (Residues: 981-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 741 16 x 741
1 modified residue:
Ligand PTR 48 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 137.34Å b: 137.02Å c: 178.99Å
α: 90° β: 110.36° γ: 90°
R-values:
R R work R free
0.212 0.21 0.258
Expression system: Homo sapiens

Quick links

Citations

2 review citations

A review on anticancer potential of bioactive heterocycle quinoline.
Afzal et al. (2015)
1 more

5 mentions without citation

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases.
Xu et al. (2015)
4 more