› 3f7r

X-ray diffraction
2.04Å resolution

First pair of Fibronectin type III domains and part of the connecting segment of the integrin beta4

Released:
DOI: 10.2210/pdb3f7r/pdb
PDB entry 3f7r coloured by chain, front view.
PDB entry 3f7r coloured by chain, side view.
PDB entry 3f7r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes.
de Pereda JM, Lillo MP, Sonnenberg A
EMBO J 28 1180-90 (2009)
PMID: 19242489

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-4 Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 27.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16144 (Residues: 1126-1369; Coverage: 14%)
Gene name: ITGB4
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand CL 1 x CL
Ligand PEG 2 x PEG
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: C2
Unit cell:
a: 137.5Å b: 42.15Å c: 56.91Å
α: 90° β: 109.92° γ: 90°
R-values:
R R work R free
0.178 0.176 0.215
Expression system: Escherichia coli BL21(DE3)

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Citations

18 review citations

Type VII collagen: the anchoring fibril protein at fault in dystrophic epidermolysis bullosa.
Chung et al. (2010)
17 more

1 mention without citation

Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes.
de Pereda et al. (2009)