Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Endopeptidase for which the P1 residue is preferably hydrophobic.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assemblies composition:
Assembly name:
Integrase and PC4 and SFRS1-interacting protein (preferred)
PDBe Complex ID:
PDB-CPX-130986 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrase
Molecule details ›
Chains: A, B, E, F, I, J, M, N, Q, R, U, V, Y, Z, c, d, g, h, k, l, o, p, s, t
Length: 210 amino acids
Theoretical weight: 23.67 KDa
Source organism: Human immunodeficiency virus type 2 (ISOLATE ROD)
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 210 amino acids
Theoretical weight: 23.67 KDa
Source organism: Human immunodeficiency virus type 2 (ISOLATE ROD)
Expression system: Escherichia coli
UniProt:
- Canonical:
P04584 (Residues: 1173-1380; Coverage: 14%)
Sequence domains:
Structure domains:
PC4 and SFRS1-interacting protein
Molecule details ›
Chains: C, G, K, O, S, W, a, e, i, m, q, u
Length: 95 amino acids
Theoretical weight: 11.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Structure domains: Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
Length: 95 amino acids
Theoretical weight: 11.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: O75475 (Residues: 347-435; Coverage: 17%)
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Structure domains: Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
