› 3fay

X-ray diffraction
2.2Å resolution

Crystal structure of the GAP-related domain of IQGAP1

Released:
DOI: 10.2210/pdb3fay/pdb
PDB entry 3fay coloured by chain, front view.
PDB entry 3fay coloured by chain, side view.
PDB entry 3fay coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the GTPase-activating protein-related domain from IQGAP1.
Kurella VB, Richard JM, Parke CL, Lecour LF, Bellamy HD, Worthylake DK
J Biol Chem 284 14857-65 (2009)
PMID: 19321438

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras GTPase-activating-like protein IQGAP1 Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 44.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46940 (Residues: 962-1345; Coverage: 23%)
Gene names: IQGAP1, KIAA0051
Sequence domains: GTPase-activator protein for Ras-like GTPase
Structure domains: GTPase Activation - p120gap; domain 1

Ligands and Environments

1 bound ligand:
Ligand TRS 1 x TRS
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CAMD BEAMLINE GCPCC
Spacegroup: P21212
Unit cell:
a: 170.133Å b: 42.115Å c: 59.382Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.258
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils et al. (2013)
16 more

8 mentions without citation

Crystal structure of the GTPase-activating protein-related domain from IQGAP1.
Kurella et al. (2009)
7 more