› 3fcs

X-ray diffraction
2.55Å resolution

Structure of complete ectodomain of integrin aIIBb3

Released:
DOI: 10.2210/pdb3fcs/pdb
PDB entry 3fcs coloured by chain, front view.
PDB entry 3fcs coloured by chain, side view.
PDB entry 3fcs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA
Mol Cell 32 849-61 (2008)
PMID: 19111664

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138441 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Integrin alpha-IIb Chains: A, C
Molecule details ›
Chains: A, C
Length: 959 amino acids
Theoretical weight: 104.46 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08514 (Residues: 32-989; Coverage: 95%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains:
Structure domains:
Integrin beta-3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 690 amino acids
Theoretical weight: 76.32 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05106 (Residues: 27-716; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
4 bound ligands:
Ligand CA 14 x CA
Ligand NAG 5 x NAG
Ligand IMD 6 x IMD
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41
Unit cell:
a: 81.3Å b: 81.3Å c: 654.623Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.268
Expression system: Cricetulus griseus

Quick links

Citations

82 review citations

The final steps of integrin activation: the end game.
Shattil et al. (2010)
81 more

69 mentions without citation

Integrin structure, activation, and interactions.
Campbell et al. (2011)
68 more