› 3fcu

X-ray diffraction
2.9Å resolution

Structure of headpiece of integrin aIIBb3 in open conformation

Released:
DOI: 10.2210/pdb3fcu/pdb
PDB entry 3fcu coloured by chain, front view.
PDB entry 3fcu coloured by chain, side view.
PDB entry 3fcu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA
Mol Cell 32 849-61 (2008)
PMID: 19111664

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138441 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Integrin alpha-IIb heavy chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 457 amino acids
Theoretical weight: 49.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08514 (Residues: 32-488; Coverage: 45%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: FG-GAP repeat
Structure domains: Integrin alpha, N-terminal
Integrin beta-3 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 461 amino acids
Theoretical weight: 50.97 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05106 (Residues: 27-487; Coverage: 61%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
4 bound ligands:
Ligand CA 18 x CA
Ligand NAG 8 x NAG
Ligand MG 6 x MG
Ligand CAC 3 x CAC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P62
Unit cell:
a: 332.093Å b: 332.093Å c: 88.288Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.174 0.197
Expression system: Cricetulus griseus

Quick links

Citations

84 review citations

The final steps of integrin activation: the end game.
Shattil et al. (2010)
83 more

17 mentions without citation

ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling.
Qin et al. (2012)
16 more