› 3ff6

X-ray diffraction
3.19Å resolution

Human ACC2 CT domain with CP-640186

Released:
DOI: 10.2210/pdb3ff6/pdb
PDB entry 3ff6 coloured by chain, front view.
PDB entry 3ff6 coloured by chain, side view.
PDB entry 3ff6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
Madauss KP, Burkhart WA, Consler TG, Cowan DJ, Gottschalk WK, Miller AB, Short SA, Tran TB, Williams SP
Acta Crystallogr D Biol Crystallogr 65 449-61 (2009)
PMID: 19390150

Function and Biology Details

Reaction catalysed: 
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126389 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-CoA carboxylase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 760 amino acids
Theoretical weight: 86.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00763 (Residues: 1693-2450; Coverage: 31%)
Gene names: ACACB, ACC2, ACCB
Sequence domains: Carboxyl transferase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand RCP 4 x RCP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM, APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 81.545Å b: 168.836Å c: 293.353Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.197 0.251
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Acetyl-CoA Carboxylases and Diseases.
Wang et al. (2022)
1 more

4 mentions without citation

The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
Madauss et al. (2009)
3 more