› 3fj5

X-ray diffraction
1.65Å resolution

Crystal structure of the c-src-SH3 domain

Released:
DOI: 10.2210/pdb3fj5/pdb
PDB entry 3fj5 coloured by chain, front view.
PDB entry 3fj5 coloured by chain, side view.
PDB entry 3fj5 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Intertwined dimeric structure for the SH3 domain of the c-Src tyrosine kinase induced by polyethylene glycol binding.
Cámara-Artigas A, Martín-García JM, Morel B, Ruiz-Sanz J, Luque I
FEBS Lett 583 749-53 (2009)
PMID: 19185573

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132654 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 57 amino acids
Theoretical weight: 6.54 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 85-140; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

5 bound ligands:
Ligand PGE 1 x PGE
Ligand SO4 1 x SO4
Ligand ACT 3 x ACT
Ligand GOL 1 x GOL
Ligand PG4 2 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM16
Spacegroup: P65
Unit cell:
a: 46.596Å b: 46.596Å c: 128.064Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.206 0.222
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Crystallographic studies on protein misfolding: Domain swapping and amyloid formation in the SH3 domain.
Cámara-Artigas A. (2016)
10 other articles

3 mentions without citation

Linking in domain-swapped protein dimers.
Baiesi et al. (2016)
2 more