› 3flg

X-ray diffraction
1.8Å resolution

The PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta

Released:
DOI: 10.2210/pdb3flg/pdb
PDB entry 3flg coloured by chain, front view.
PDB entry 3flg coloured by chain, side view.
PDB entry 3flg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Amaya MF, Zeng H, MacKenzie F, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Botchkarev A, Min J, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA (cytosine-5)-methyltransferase 3B Chain: A
Molecule details ›
Chain: A
Length: 151 amino acids
Theoretical weight: 16.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBC3 (Residues: 206-355; Coverage: 18%)
Gene name: DNMT3B
Sequence domains: PWWP domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: P21212
Unit cell:
a: 54.17Å b: 75.062Å c: 34.488Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.244
Expression system: Escherichia coli

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