› 3fn3

X-ray diffraction
2.7Å resolution

Dimeric Structure of PD-L1

Released:
DOI: 10.2210/pdb3fn3/pdb
PDB entry 3fn3 coloured by chain, front view.
PDB entry 3fn3 coloured by chain, side view.
PDB entry 3fn3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A dimeric structure of PD-L1: functional units or evolutionary relics?
Chen Y, Liu P, Gao F, Cheng H, Qi J, Gao GF
Protein Cell 1 153-60 (2010)
PMID: 21203985

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death 1 ligand 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 25.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZQ7 (Residues: 19-238; Coverage: 81%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2221
Unit cell:
a: 71.865Å b: 91.373Å c: 140.316Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.226 0.296
Expression system: Escherichia coli

Quick links

Citations

8 review citations

PD-L1 Distribution and Perspective for Cancer Immunotherapy-Blockade, Knockdown, or Inhibition.
Wu et al. (2019)
7 more

20 mentions without citation

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
Zak et al. (2016)
19 more