› 3fq4

X-ray diffraction
1.49Å resolution

Crystal structure of the Calx-beta domain of integrin beta4

Released:
DOI: 10.2210/pdb3fq4/pdb
PDB entry 3fq4 coloured by chain, front view.
PDB entry 3fq4 coloured by chain, side view.
PDB entry 3fq4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Calx-beta domain of the integrin beta4 subunit: insights into function and cation-independent stability.
Alonso-García N, Inglés-Prieto A, Sonnenberg A, de Pereda JM
Acta Crystallogr D Biol Crystallogr 65 858-71 (2009)
PMID: 19622870

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16144 (Residues: 989-1107; Coverage: 7%)
Gene name: ITGB4
Sequence domains: Calx-beta domain
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P212121
Unit cell:
a: 50.31Å b: 51.66Å c: 87.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.155 0.188
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Chapter 22: Structural and signaling functions of integrins.
Kadry et al. (2020)
4 more

1 mention without citation

Advances and perspectives of the architecture of hemidesmosomes: lessons from structural biology.
de Pereda et al. (2009)