› 3frt

X-ray diffraction
4Å resolution

The structure of human CHMP3 (residues 8 - 222).

Released:
DOI: 10.2210/pdb3frt/pdb
PDB entry 3frt coloured by chain, front view.
PDB entry 3frt coloured by chain, side view.
PDB entry 3frt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for ESCRT-III protein autoinhibition.
Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI
Nat Struct Mol Biol 16 754-62 (2009)
PMID: 19525971

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195206 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Charged multivesicular body protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 218 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3E7 (Residues: 8-222; Coverage: 97%)
Gene names: CGI-149, CGI149, CHMP3, NEDF, VPS24
Sequence domains: Snf7

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 36.472Å b: 131.514Å c: 48.508Å
α: 90° β: 108.06° γ: 90°
R-values:
R R work R free
0.388 0.383 0.436
Expression system: Escherichia coli

Quick links

Citations

38 review citations

The ESCRT pathway.
Henne et al. (2011)
37 more

17 mentions without citation

The ESCRT machinery: from the plasma membrane to endosomes and back again.
Schuh et al. (2014)
16 more