› 3fvn

X-ray diffraction
1.5Å resolution

Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 9-deoxy-neodysiherbaine A in space group P1

Released:
DOI: 10.2210/pdb3fvn/pdb
PDB entry 3fvn coloured by chain, front view.
PDB entry 3fvn coloured by chain, side view.
PDB entry 3fvn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.
Unno M, Shinohara M, Takayama K, Tanaka H, Teruya K, Doh-ura K, Sakai R, Sasaki M, Ikeda-Saito M
J Mol Biol 413 667-83 (2011)
PMID: 21893069

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-153824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 29.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P39086 (Residues: 445-559, 682-820; Coverage: 29%)
Gene names: GLUR5, GRIK1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand GOL 8 x GOL
Ligand 9DX 2 x 9DX
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P1
Unit cell:
a: 47.55Å b: 50.814Å c: 63.037Å
α: 80.38° β: 84.37° γ: 62.09°
R-values:
R R work R free
0.173 0.172 0.19
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
1 more