› 3fxw

X-ray diffraction
2Å resolution

High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3/inhibitor 2 complex

Released:
DOI: 10.2210/pdb3fxw/pdb
PDB entry 3fxw coloured by chain, front view.
PDB entry 3fxw coloured by chain, side view.
PDB entry 3fxw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Cheng RKY, Barker J, Palan S, Felicetti B, Whittaker M, Hesterkamp T

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-activated protein kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 336 amino acids
Theoretical weight: 38.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16644 (Residues: 33-349; Coverage: 83%)
Gene name: MAPKAPK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand F10 1 x F10
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 85.294Å b: 75.555Å c: 61.731Å
α: 90° β: 108.91° γ: 90°
R-values:
R R work R free
0.235 0.233 0.277
Expression system: Escherichia coli

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