› 3g0j

X-ray diffraction
1.78Å resolution

Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1)

Released:
DOI: 10.2210/pdb3g0j/pdb
PDB entry 3g0j coloured by chain, front view.
PDB entry 3g0j coloured by chain, side view.
PDB entry 3g0j coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Keates T, Picaud S, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein polybromo-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 14.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86U86 (Residues: 645-766; Coverage: 7%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand EDO 4 x EDO
Ligand NO3 1 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Unit cell:
a: 36.57Å b: 57.37Å c: 137.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.237
Expression system: Escherichia coli

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