› 3gav

X-ray solution scattering

Solution structure of Human Complement Factor H in 137 mM NaCl buffer

Released:
DOI: 10.2210/pdb3gav/pdb
PDB entry 3gav coloured by chain, ensemble of 8 models, front view.
PDB entry 3gav coloured by chain, ensemble of 8 models, side view.
PDB entry 3gav coloured by chain, ensemble of 8 models, top view.
Source organism: Homo sapiens
Primary publication:
Electrostatic interactions contribute to the folded-back conformation of wild type human factor H.
Okemefuna AI, Nan R, Gor J, Perkins SJ
J Mol Biol 391 98-118 (2009)
PMID: 19505476

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: A
Molecule details ›
Chain: A
Length: 1213 amino acids
Theoretical weight: 137.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08603 (Residues: 19-1231; Coverage: 100%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Quick links

Citations

7 review citations

Complement control protein factor H: the good, the bad, and the inadequate.
Ferreira et al. (2010)
6 more

6 mentions without citation

Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations.
Okemefuna et al. (2010)
5 more