› 3gd8

X-ray diffraction
1.8Å resolution

Crystal Structure of Human Aquaporin 4 at 1.8 and its Mechanism of Conductance

Released:
DOI: 10.2210/pdb3gd8/pdb
PDB entry 3gd8 coloured by chain, front view.
PDB entry 3gd8 coloured by chain, side view.
PDB entry 3gd8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.
Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM
Proc Natl Acad Sci U S A 106 7437-42 (2009)
PMID: 19383790

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157198 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aquaporin-4 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.53 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P55087 (Residues: 32-254; Coverage: 69%)
Gene name: AQP4
Sequence domains: Major intrinsic protein
Structure domains: Glycerol uptake facilitator protein.

Ligands and Environments

2 bound ligands:
Ligand GOL 5 x GOL
Ligand BOG 1 x BOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P4212
Unit cell:
a: 82.058Å b: 82.058Å c: 76.353Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.16 0.165
Expression system: Komagataella pastoris

Quick links

Citations

55 review citations

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance.
Jarius et al. (2010)
54 more

73 mentions without citation

Aquaporin water channels in the nervous system.
Papadopoulos et al. (2013)
72 more