› 3gdi

X-ray diffraction
2.4Å resolution

Mammalian Clock Protein mPER2 - Crystal Structure of a PAS Domain Fragment

Released:
DOI: 10.2210/pdb3gdi/pdb
PDB entry 3gdi coloured by chain, front view.
PDB entry 3gdi coloured by chain, side view.
PDB entry 3gdi coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2.
Hennig S, Strauss HM, Vanselow K, Yildiz O, Schulze S, Arens J, Kramer A, Wolf E
PLoS Biol 7 e94 (2009)
PMID: 19402751

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129525 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Period circadian protein homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 35.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O54943 (Residues: 170-473; Coverage: 24%)
Gene name: Per2
Sequence domains:
Structure domains: PAS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 69.67Å b: 63.38Å c: 72.51Å
α: 90° β: 102.25° γ: 90°
R-values:
R R work R free
0.264 0.224 0.272
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Circadian Oscillators: Around the Transcription-Translation Feedback Loop and on to Output.
Hurley et al. (2016)
10 more

16 mentions without citation

Emerging models for the molecular basis of mammalian circadian timing.
Gustafson et al. (2015)
15 more