› 3ghn

X-ray diffraction
2.8Å resolution

Crystal structure of the exosite-containing fragment of human ADAMTS13 (form-2)

Released:
DOI: 10.2210/pdb3ghn/pdb
PDB entry 3ghn coloured by chain, front view.
PDB entry 3ghn coloured by chain, side view.
PDB entry 3ghn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T

Function and Biology Details

Reaction catalysed: 
The enzyme cleaves the von Willebrand factor at bond 842-Tyr-|-Met-843 within the A2 domain
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
A disintegrin and metalloproteinase with thrombospondin motifs 13 Chain: A
Molecule details ›
Chain: A
Length: 419 amino acids
Theoretical weight: 46.53 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q76LX8 (Residues: 287-685; Coverage: 29%)
Gene names: ADAMTS13, C9orf8, UNQ6102/PRO20085
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: FUC, BGC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 138.577Å b: 51.37Å c: 76.371Å
α: 90° β: 106.75° γ: 90°
R-values:
R R work R free
0.229 0.229 0.28
Expression system: Cricetulus griseus

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