› 3gsl

X-ray diffraction
2.05Å resolution

Crystal structure of PSD-95 tandem PDZ domains 1 and 2

Released:
DOI: 10.2210/pdb3gsl/pdb
PDB entry 3gsl coloured by chain, front view.
PDB entry 3gsl coloured by chain, side view.
PDB entry 3gsl coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.
Sainlos M, Tigaret C, Poujol C, Olivier NB, Bard L, Breillat C, Thiolon K, Choquet D, Imperiali B
Nat Chem Biol 7 81-91 (2011)
PMID: 21186349

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151877 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 196 amino acids
Theoretical weight: 20.79 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P31016 (Residues: 61-249; Coverage: 26%)
Gene names: Dlg4, Dlgh4, Psd95
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P21
Unit cell:
a: 57.244Å b: 62.511Å c: 59.342Å
α: 90° β: 99.25° γ: 90°
R-values:
R R work R free
0.221 0.214 0.281
Expression system: Escherichia coli BL21

Quick links

Citations

21 review citations

Mechanisms of CaMKII action in long-term potentiation.
Lisman et al. (2012)
20 more

9 mentions without citation

Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.
Coles et al. (2015)
8 more