› 3gv3

X-ray diffraction
1.6Å resolution

CXCL12 (SDF) in trigonal space group

Released:
DOI: 10.2210/pdb3gv3/pdb
PDB entry 3gv3 coloured by chain, front view.
PDB entry 3gv3 coloured by chain, side view.
PDB entry 3gv3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family.
Murphy JW, Yuan H, Kong Y, Xiong Y, Lolis EJ
Proteins 78 1331-7 (2010)
PMID: 20077567

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155706 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SDF-1-alpha(3-67) Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 7.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48061 (Residues: 26-88; Coverage: 88%)
Gene names: CXCL12, SDF1, SDF1A, SDF1B
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3221
Unit cell:
a: 55.51Å b: 55.51Å c: 45.963Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.247
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth.
Gacche et al. (2013)
5 more

12 mentions without citation

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives.
Pawig et al. (2015)
11 more