› 3gw0

X-ray diffraction
2Å resolution

UROD mutant G318R

Released:
DOI: 10.2210/pdb3gw0/pdb
PDB entry 3gw0 coloured by chain, front view.
PDB entry 3gw0 coloured by chain, side view.
PDB entry 3gw0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases.
Warby CA, Phillips JD, Bergonia HA, Whitby FG, Hill CP, Kushner JP
Cell Mol Biol (Noisy-le-grand) 55 40-5 (2009)
PMID: 19656450

Function and Biology Details

Reaction catalysed: 
Uroporphyrinogen III = coproporphyrinogen + 4 CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138879 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uroporphyrinogen decarboxylase Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 40.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06132 (Residues: 1-367; Coverage: 100%)
Gene name: UROD
Sequence domains: Uroporphyrinogen decarboxylase (URO-D)
Structure domains: TIM Barrel

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 103.266Å b: 103.266Å c: 73.389Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.24
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structural aspects of enzymes involved in prokaryotic Gram-positive heme biosynthesis.
Falb et al. (2023)

1 mention without citation

Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases.
Warby et al. (2009)