› 3gxl

X-ray diffraction
1.8Å resolution

ALK-5 kinase complex with GW857175

Released:
DOI: 10.2210/pdb3gxl/pdb
PDB entry 3gxl coloured by chain, front view.
PDB entry 3gxl coloured by chain, side view.
PDB entry 3gxl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors.
Gellibert F, Fouchet MH, Nguyen VL, Wang R, Krysa G, de Gouville AC, Huet S, Dodic N
Bioorg Med Chem Lett 19 2277-81 (2009)
PMID: 19285388

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-1 Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 34.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 201-503; Coverage: 65%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand QIG 1 x QIG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 41.839Å b: 74.618Å c: 89.652Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.262
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.
Asif M. (2014)
2 more

5 mentions without citation

Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy.
Guven-Maiorov et al. (2014)
4 more