Function and Biology Details
Reaction catalysed:
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171762 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
NEDD8-activating enzyme E1 regulatory subunit
Molecule details ›
Chains: A, C
Length: 534 amino acids
Theoretical weight: 60.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: ThiF family
Structure domains: NAD(P)-binding Rossmann-like Domain
Length: 534 amino acids
Theoretical weight: 60.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q13564 (Residues: 1-534; Coverage: 100%)
Sequence domains: ThiF family
Structure domains: NAD(P)-binding Rossmann-like Domain
NEDD8-activating enzyme E1 catalytic subunit
Molecule details ›
Chains: B, D
Length: 463 amino acids
Theoretical weight: 51.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains:
Length: 463 amino acids
Theoretical weight: 51.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q8TBC4 (Residues: 1-463; Coverage: 100%)
Sequence domains:
Structure domains:
NEDD8
Molecule details ›
Chains: I, J
Length: 82 amino acids
Theoretical weight: 9.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Length: 82 amino acids
Theoretical weight: 9.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q15843 (Residues: 1-76; Coverage: 94%)
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
