› 3gzq

X-ray diffraction
1.4Å resolution

HUMAN SOD1 A4V Metal-free Variant

Released:
DOI: 10.2210/pdb3gzq/pdb
PDB entry 3gzq coloured by chain, front view.
PDB entry 3gzq coloured by chain, side view.
PDB entry 3gzq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A.
Galaleldeen A, Strange RW, Whitson LJ, Antonyuk SV, Narayana N, Taylor AB, Schuermann JP, Holloway SP, Hasnain SS, Hart PJ
Arch Biochem Biophys 492 40-7 (2009)
PMID: 19800308

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B
Molecule details ›
Chains: A, B
Length: 154 amino acids
Theoretical weight: 15.88 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P00441 (Residues: 2-154; Coverage: 99%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)
Structure domains: Superoxide dismutase, copper/zinc binding domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 40.513Å b: 58.811Å c: 104.938Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.164 0.193
Expression system: Saccharomyces cerevisiae

Quick links

Citations

3 review citations

Superoxide dismutases and superoxide reductases.
Sheng et al. (2014)
2 more

3 mentions without citation

Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants.
Huai et al. (2019)
2 more