3h3g

X-ray diffraction
1.94Å resolution

Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in complex with parathyroid hormone-related protein (PTHrP)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-142551 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Maltose/maltodextrin-binding periplasmic protein; Parathyroid hormone/parathyroid hormone-related peptide receptor Chain: A
Molecule details ›
Chain: A
Length: 539 amino acids
Theoretical weight: 60.3 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 25-392; Coverage: 99%)
  • Canonical: Q03431 (Residues: 29-187; Coverage: 28%)
Gene names: JW3994, PTH1R, PTHR, PTHR1, b4034, malE
Sequence domains:
Structure domains:
PTHrP[1-36] Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.76 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P12272 (Residues: 48-70; Coverage: 15%)
Gene names: PTHLH, PTHRP

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P41212
Unit cell:
a: 84.041Å b: 84.041Å c: 164.455Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.233
Expression systems:
  • Escherichia coli
  • Not provided