› 3h9y

X-ray diffraction
2.23Å resolution

Crystal structure of the IgE-Fc3-4 domains

Released:
DOI: 10.2210/pdb3h9y/pdb
PDB entry 3h9y coloured by chain, front view.
PDB entry 3h9y coloured by chain, side view.
PDB entry 3h9y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.
Wurzburg BA, Jardetzky TS
J Mol Biol 393 176-90 (2009)
PMID: 19682998

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Immunoglobulin heavy constant epsilon Chains: A, B, E
Molecule details ›
Chains: A, B, E
Length: 223 amino acids
Theoretical weight: 24.92 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01854 (Residues: 209-427; Coverage: 40%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NH4 1 x NH4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: C2
Unit cell:
a: 153.676Å b: 104.994Å c: 49.222Å
α: 90° β: 101.61° γ: 90°
R-values:
R R work R free
0.233 0.231 0.262
Expression system: Trichoplusia ni

Quick links

Citations

4 review citations

Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII.
Sutton et al. (2015)
3 more

4 mentions without citation

Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.
Wurzburg et al. (2009)
3 more