› 3hfc

X-ray diffraction
2.45Å resolution

A trimeric form of the Kv7.1 A domain Tail, L602M/L606M mutant Semet

Released:
DOI: 10.2210/pdb3hfc/pdb
PDB entry 3hfc coloured by chain, front view.
PDB entry 3hfc coloured by chain, side view.
PDB entry 3hfc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif.
Xu Q, Minor DL
Protein Sci 18 2100-14 (2009)
PMID: 19693805

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156414 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily KQT member 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 31 amino acids
Theoretical weight: 3.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51787 (Residues: 583-611; Coverage: 4%)
Gene names: KCNA8, KCNA9, KCNQ1, KVLQT1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2
Unit cell:
a: 60.431Å b: 41.232Å c: 34.723Å
α: 90° β: 119.26° γ: 90°
R-values:
R R work R free
0.223 0.221 0.269
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Structural biology of TRP channels.
Hellmich et al. (2014)
3 more

2 mentions without citation

Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif.
Xu et al. (2009)
1 more