Function and Biology Details
Reaction catalysed:
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145614 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-degrading enzyme
Molecule details ›
Chains: A, B
Length: 969 amino acids
Theoretical weight: 112.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 969 amino acids
Theoretical weight: 112.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P14735 (Residues: 43-1011; Coverage: 95%)
Sequence domains:
- Insulinase (Peptidase family M16)
- Peptidase M16 inactive domain
- Middle or third domain of peptidase_M16
Islet amyloid polypeptide
Molecule details ›
Chains: D, E
Length: 37 amino acids
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Calcitonin / CGRP / IAPP family
Length: 37 amino acids
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Sequence domains: Calcitonin / CGRP / IAPP family
