› 3hk0

X-ray diffraction
2.6Å resolution

Crystal Structure of the RA and PH Domains of Grb10

Released:
DOI: 10.2210/pdb3hk0/pdb
PDB entry 3hk0 coloured by chain, front view.
PDB entry 3hk0 coloured by chain, side view.
PDB entry 3hk0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Depetris RS, Wu J, Hubbard SR
Nat Struct Mol Biol 16 833-9 (2009)
PMID: 19648926

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 29.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13322 (Residues: 164-415; Coverage: 42%)
Gene names: GRB10, GRBIR, KIAA0207
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SCN 1 x SCN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 126.875Å b: 48.884Å c: 92.217Å
α: 90° β: 114.14° γ: 90°
R-values:
R R work R free
0.232 0.23 0.277
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.
Scheffzek et al. (2012)
7 more

12 mentions without citation

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Depetris et al. (2009)
11 more