› 3hkk

X-ray diffraction
2.9Å resolution

Structure of human Leukotriene C4 synthase in complex with glutathione sulfonate

Released:
DOI: 10.2210/pdb3hkk/pdb
PDB entry 3hkk coloured by chain, front view.
PDB entry 3hkk coloured by chain, side view.
PDB entry 3hkk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rinaldo-Matthis A, Haeggstrom JZ

Function and Biology Details

Reaction catalysed: 
Leukotriene C(4) = leukotriene A(4) + glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172606 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene C4 synthase Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.41 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q16873 (Residues: 2-150; Coverage: 99%)
Gene name: LTC4S
Sequence domains: MAPEG family
Structure domains: Membrane associated eicosanoid/glutathione metabolism-like domain

Ligands and Environments


Cofactor: Ligand GTS 1 x GTS
2 bound ligands:
Ligand PAM 1 x PAM
Ligand PLM 6 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: F23
Unit cell:
a: 170.718Å b: 170.718Å c: 170.718Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.232
Expression system: Komagataella pastoris

Quick links