› 3hm6

X-ray diffraction
2.4Å resolution

Crystal structure of the cytoplasmic domain of human plexin B1

Released:
DOI: 10.2210/pdb3hm6/pdb
PDB entry 3hm6 coloured by chain, front view.
PDB entry 3hm6 coloured by chain, side view.
PDB entry 3hm6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
Tong Y, Hota PK, Penachioni JY, Hamaneh MB, Kim S, Alviani RS, Shen L, He H, Tempel W, Tamagnone L, Park HW, Buck M
J Biol Chem 284 35962-72 (2009)
PMID: 19843518

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128845 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Plexin-B1 Chain: X
Molecule details ›
Chain: X
Length: 644 amino acids
Theoretical weight: 73.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43157 (Residues: 1511-2135; Coverage: 30%)
Gene names: KIAA0407, PLXN5, PLXNB1, SEP
Sequence domains:
Structure domains:
Unknown peptide Chain: C
Molecule details ›
Chain: C
Length: 27 amino acids
Theoretical weight: 2.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

1 bound ligand:
Ligand UNX 19 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P3121
Unit cell:
a: 74.346Å b: 74.346Å c: 214.398Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.227 0.262
Expression system: Spodoptera frugiperda

Quick links

Citations

15 review citations

Semaphorins and plexins as therapeutic targets.
Worzfeld et al. (2014)
14 more

9 mentions without citation

Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
Tong et al. (2009)
8 more