› 3hm8

X-ray diffraction
2.8Å resolution

Crystal structure of the C-terminal Hexokinase domain of human HK3

Released:
DOI: 10.2210/pdb3hm8/pdb
PDB entry 3hm8 coloured by chain, front view.
PDB entry 3hm8 coloured by chain, side view.
PDB entry 3hm8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nedyalkova L, Tong Y, Rabeh W, Tempel W, Landry R, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 445 amino acids
Theoretical weight: 48.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52790 (Residues: 480-922; Coverage: 48%)
Gene name: HK3
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GLC 4 x GLC
Ligand BG6 4 x BG6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41
Unit cell:
a: 83.904Å b: 83.904Å c: 323.327Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.245 0.27
Expression system: Escherichia coli

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