Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Interleukin-12 complex and antibody (preferred)
PDBe Complex ID:
PDB-CPX-210992 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Interleukin-12 subunit beta
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Cytokine interleukin-12p40 C-terminus
Structure domains: Immunoglobulins
Length: 306 amino acids
Theoretical weight: 34.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P29460 (Residues: 23-328; Coverage: 100%)
Sequence domains: Cytokine interleukin-12p40 C-terminus
Structure domains: Immunoglobulins
Interleukin-12 subunit alpha
Molecule details ›
Chain: B
Length: 197 amino acids
Theoretical weight: 22.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Interleukin-12 alpha subunit
Structure domains: Growth Hormone; Chain: A;
Length: 197 amino acids
Theoretical weight: 22.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P29459 (Residues: 23-219; Coverage: 100%)
Sequence domains: Interleukin-12 alpha subunit
Structure domains: Growth Hormone; Chain: A;
Ligands and Environments
Experiments and Validation Details
X-ray source:
APS BEAMLINE 17-ID
Spacegroup:
P212121
Expression system: Homo sapiens
