› 3hnb

X-ray diffraction
1.15Å resolution

Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor

Released:
DOI: 10.2210/pdb3hnb/pdb
PDB entry 3hnb coloured by chain, front view.
PDB entry 3hnb coloured by chain, side view.
PDB entry 3hnb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.
Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M
J Biol Chem 285 8824-9 (2010)
PMID: 20089867

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Factor VIIIa light chain Chain: M
Molecule details ›
Chain: M
Length: 159 amino acids
Theoretical weight: 18.03 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P00451 (Residues: 2189-2347; Coverage: 7%)
Gene names: F8, F8C
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

1 bound ligand:
Ligand 768 1 x 768
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 42.054Å b: 55.775Å c: 67.971Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.185 0.22
Expression system: Komagataella pastoris

Quick links

Citations

4 review citations

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria.
Jones et al. (2010)
3 more

5 mentions without citation

Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.
Liu et al. (2010)
4 more