› 3ho4

X-ray diffraction
3.1Å resolution

Crystal structure of Hedgehog-interacting protein (HHIP)

Released:
DOI: 10.2210/pdb3ho4/pdb
PDB entry 3ho4 coloured by chain, front view.
PDB entry 3ho4 coloured by chain, side view.
PDB entry 3ho4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA
Nat Struct Mol Biol 16 691-7 (2009)
PMID: 19561609

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188709 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hedgehog-interacting protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 481 amino acids
Theoretical weight: 54.42 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96QV1 (Residues: 193-667; Coverage: 70%)
Gene names: HHIP, HIP, UNQ5825/PRO19644
Sequence domains:
Structure domains: Laminin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P3121
Unit cell:
a: 101.042Å b: 101.042Å c: 304.923Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.217 0.252
Expression system: Trichoplusia ni

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Citations

32 review citations

Interactions between Hedgehog proteins and their binding partners come into view.
Beachy et al. (2010)
31 more