Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Endonucleolytic cleavage to 5'-phosphomonoester.
dUTP + H(2)O = dUMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
Integrase and PC4 and SFRS1-interacting protein (preferred)
PDBe Complex ID:
PDB-CPX-130994 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrase
Molecule details ›
Chains: A, B, C, D, E, F
Length: 219 amino acids
Theoretical weight: 25.09 KDa
Source organism: Visna/maedi virus EV1 KV1772
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 219 amino acids
Theoretical weight: 25.09 KDa
Source organism: Visna/maedi virus EV1 KV1772
Expression system: Escherichia coli
UniProt:
- Canonical:
P35956 (Residues: 1228-1444; Coverage: 14%)
Sequence domains:
Structure domains:
PC4 and SFRS1-interacting protein
Molecule details ›
Chains: G, H, I, J, K, L
Length: 95 amino acids
Theoretical weight: 11.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Structure domains: Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
Length: 95 amino acids
Theoretical weight: 11.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: O75475 (Residues: 347-435; Coverage: 17%)
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Structure domains: Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
