› 3hpn

X-ray diffraction
2.52Å resolution

Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain and the EPHA2/EPHRIN-A1 complex

Released:
DOI: 10.2210/pdb3hpn/pdb
PDB entry 3hpn coloured by chain, front view.
PDB entry 3hpn coloured by chain, side view.
PDB entry 3hpn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Himanen JP, Goldgur Y, Miao H, Myshkin E, Guo H, Buck M, Nguyen M, Rajashankar KR, Wang B, Nikolov DB
EMBO Rep 10 722-8 (2009)
PMID: 19525919

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-151387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 174 amino acids
Theoretical weight: 19.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P29317 (Residues: 28-201; Coverage: 18%)
Gene names: ECK, EPHA2
Sequence domains: Ephrin receptor ligand binding domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P1
Unit cell:
a: 41.271Å b: 91.187Å c: 91.132Å
α: 117.14° β: 97.27° γ: 100.79°
R-values:
R R work R free
0.236 0.232 0.307
Expression system: Homo sapiens

Quick links

Citations

20 review citations

Mechanisms of ephrin-Eph signalling in development, physiology and disease.
Kania et al. (2016)
19 more