Function and Biology Details
Reaction catalysed:
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2)
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172548 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Egl nine homolog 1
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 27.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: 2OG-Fe(II) oxygenase superfamily
Structure domains: q2cbj1_9rhob like domain
Length: 246 amino acids
Theoretical weight: 27.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9GZT9 (Residues: 181-426; Coverage: 58%)
Sequence domains: 2OG-Fe(II) oxygenase superfamily
Structure domains: q2cbj1_9rhob like domain
Hypoxia-inducible factor 1-alpha
Molecule details ›
Chain: S
Length: 17 amino acids
Theoretical weight: 2.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Hypoxia-inducible factor-1
Length: 17 amino acids
Theoretical weight: 2.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: Q16665 (Residues: 558-574; Coverage: 2%)
Sequence domains: Hypoxia-inducible factor-1
