› 3hr0

X-ray diffraction
1.9Å resolution

Crystal structure of Homo sapiens Conserved Oligomeric Golgi subunit 4

Released:
DOI: 10.2210/pdb3hr0/pdb
PDB entry 3hr0 coloured by chain, front view.
PDB entry 3hr0 coloured by chain, side view.
PDB entry 3hr0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.
Richardson BC, Smith RD, Ungar D, Nakamura A, Jeffrey PD, Lupashin VV, Hughson FM
Proc Natl Acad Sci U S A 106 13329-34 (2009)
PMID: 19651599

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Conserved oligomeric Golgi complex subunit 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H9E3 (Residues: 525-785; Coverage: 33%)
Gene name: COG4
Sequence domains: Conserved oligomeric Golgi complex subunit 4, C-terminal
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3221
Unit cell:
a: 87.114Å b: 87.114Å c: 214.773Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.222
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Role of Rab GTPases in membrane traffic and cell physiology.
Hutagalung et al. (2011)
14 more

8 mentions without citation

Structure of Golgi transport proteins.
Kümmel et al. (2011)
7 more