› 3hx3

X-ray diffraction
1.69Å resolution

Crystal structure of CRALBP mutant R234W

Released:
DOI: 10.2210/pdb3hx3/pdb
PDB entry 3hx3 coloured by chain, front view.
PDB entry 3hx3 coloured by chain, side view.
PDB entry 3hx3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.
He X, Lobsiger J, Stocker A
Proc Natl Acad Sci U S A 106 18545-50 (2009)
PMID: 19846785

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146114 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinaldehyde-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12271 (Residues: 2-317; Coverage: 100%)
Gene names: CRALBP, RLBP1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand RET 1 x RET
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 87.93Å b: 57.88Å c: 75.15Å
α: 90° β: 122.85° γ: 90°
R-values:
R R work R free
0.169 0.167 0.184
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Chemistry and biology of vision.
Palczewski K. (2012)
13 more

6 mentions without citation

Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.
He et al. (2009)
5 more