› 3hy5

X-ray diffraction
3.04Å resolution

Crystal structure of CRALBP

Released:
DOI: 10.2210/pdb3hy5/pdb
PDB entry 3hy5 coloured by chain, front view.
PDB entry 3hy5 coloured by chain, side view.
PDB entry 3hy5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.
He X, Lobsiger J, Stocker A
Proc Natl Acad Sci U S A 106 18545-50 (2009)
PMID: 19846785

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146114 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinaldehyde-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12271 (Residues: 2-317; Coverage: 100%)
Gene names: CRALBP, RLBP1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand RET 1 x RET
Ligand TLA 1 x TLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P6522
Unit cell:
a: 71.93Å b: 71.93Å c: 303.16Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.242 0.239 0.272
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Chemistry of the retinoid (visual) cycle.
Kiser et al. (2014)
11 more

7 mentions without citation

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.
von Lintig et al. (2010)
6 more