3hym

X-ray diffraction
2.8Å resolution

Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero dodecamer
hetero tetramer
PDBe Complex ID:
PDB-CPX-171509 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Anaphase-promoting complex subunit CDC26 Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 29 amino acids
Theoretical weight: 3.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NHZ8 (Residues: 1-29; Coverage: 34%)
Gene names: ANAPC12, C9orf17, CDC26
Sequence domains: Anaphase-promoting complex APC subunit CDC26
Cell division cycle protein 16 homolog Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 330 amino acids
Theoretical weight: 37.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13042 (Residues: 212-539; Coverage: 53%)
Gene names: ANAPC6, CDC16
Sequence domains: Tetratricopeptide repeat
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P63
Unit cell:
a: 301.897Å b: 301.897Å c: 80.168Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.188 0.22
Expression system: Escherichia coli